• Translational Precision in Gene Expression: Mechanistic I...

  2025-10-16

  This thought-leadership article explores the mechanistic, experimental, and translational frontiers of first-strand cDNA synthesis from total RNA, emphasizing how innovations in reverse transcription—exemplified by the HyperScript™ First-Strand cDNA Synthesis Kit—enable researchers to overcome complex RNA secondary structures and low-abundance targets. Drawing on current scientific literature, including pivotal studies in leukemia, and positioning these insights within a competitive and clinical context, the article offers actionable strategies and a forward-looking perspective for translational researchers seeking robust gene expression analysis.

• NVP-BHG712 It has been suggested that the suppression

  2023-07-06

  

  It has been suggested that the suppression of 5-LOX could promote apoptotic signaling pathways in cancers [6]. However, the role of 5-LOX in modulating apoptotic factors and neutrophil activation during ANP has not yet been evaluated. In this study, we aimed to evaluate the expression of 5-LOX in p

• Herein we disclose novel dihydropyrano c pyrazoles that inhi

  2023-07-06

  

  Herein, we disclose novel 2,4-dihydropyrano[2,3-c]pyrazoles that inhibit human ATX (hATX). Our results demonstrate and further support previous findings showing that a desired biological action can be achieved without targeting the catalytic site of the enzyme. Moreover, this study validated hen egg

• br Author contributions br Competing interests br

  2023-07-06

  

  Author contributions Competing interests Transparency document Acknowledgments This research was funded by a TOP ZonMW grant (40-00812-98-10054) to R.O.E., a DFG grant (KR4391/1-1) and IZKF Erlangen grant (J36) to A.K. and supported in part by Centro de Investigación Biomédica en Red de

• Although plant Aurora kinases can be clearly grouped

  2023-07-05

  

  Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of

• To maintain ATP levels postmortem muscle mobilizes its glyco

  2023-07-05

  

  To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield Triacetyl Resveratrol australia 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (Pinitiation of the experiment. We expected that if myosin

• The MOB and AOB are important

  2023-07-05

  

  The MOB and AOB are important in ungulates (Keller and Levy, 2012, Sanchez-Andrade and Kendrick, 2009), which rely heavily on odorant information for social interactions (Baum and Cherry, 2015, Keller and Levy, 2012, Osada et al., 2014, Villagran and Ungerfeld, 2013). The release of GABA and glutama

• Introduction Hepatocellular carcinoma HCC is one of

  2023-07-05

  

  Introduction Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat, and it threatens human health severely [1]. Although various interventions, including surgical operation, radiofrequency ablation, and chemotherapy, have been endorsed, the prognosis of HCC patients remains p

• br Nanoparticle Conjugated Topoisomerase Inhibitors The safe

  2023-07-05

  

  Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5

• The excellent safety profile of solanezumab

  2023-07-05

  

  The excellent safety profile of solanezumab and encouraging trends in the exploratory analyses in mild AD led to its inclusion in two secondary prevention trials, which are continuing in the hope that earlier intervention may yield more substantial benefit. The A4 study (NCT02008357) started in Febr

• Pimozide Discussion The present experiments follow up

  2023-07-05

  

  Discussion The present experiments follow-up and are completely consistent with our prior findings [26] that blood Aβ is subject to peripheral clearance by a major pathway for circulating pathogens in primates, immune adherence [30,31]. CR1-mediated erythrocyte immune adherence, as well as CR1-medi

• However in recent years advanced experiments and findings ar

  2023-07-05

  

  However, in recent years advanced experiments and findings are emerging to give us more detailed information on Aβ-membrane interactions. Several reviews have provided background on the fibrillation of Aβ and the Aβ-membrane interactions [[18], [19], [20], [21], [22]]. In this review, we mainly focu

• br Endoplasmic reticulum protein ERp binds to

  2023-07-05

  

  Endoplasmic reticulum protein 46 (ERp46) binds to AdipoR1 in HeLa cells ERp46 is localized in the ER and is suggested to act as a chaperone. About 20% of endogenous ERp46 are found at the plasma membrane suggesting that this protein may have additional functions. ERp46 interacts with GF 109203X 1

• Tissue distribution showed that ctrp was abundantly

  2023-07-05

  

  Tissue distribution showed that ctrp9 was abundantly expressed in the kidney of male and female tilapia. In mice, the Ctrp9 was identified in adipose tissue, and the expression levels were higher in females than that of males (Wong et al., 2009). Recent studies indicated that Ctrp9 was also expresse

• AMPK is an essential player in adiponectin signaling pathway

  2023-07-05

  

  AMPK is an essential player in adiponectin signaling pathway that regulates energy metabolism. The fact that suppression of AMPK activity by compound C largely diminished candesartan-mediated inhibition of NFκB via blocking AT1 also suggests that the AT1-mediated effect is at least partly resulted f

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