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Histamine modulates an attentional state which
2022-04-09

Histamine modulates an attentional state, which might affect performances in the object recognition test. Indeed, systemic injection of H3 receptor inverse agonists enhances the attentional state (41). However, the memory recovery in our study is unlikely to be due to the enhanced attentional state.
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br Methods br Acknowledgements We are grateful
2022-04-09

Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo
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LPCs have been previously described as
2022-04-08

LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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br Introduction Adipose tissue AT in addition to its
2022-04-08

Introduction Adipose tissue (AT), in addition to its function as fak pathway storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inflammation. One imp
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We found that most antigenic regions in
2022-04-08

We found that most antigenic regions in GlyT1C are located in the second half of the GlyT1C-terminus, which is in concert with previously published results (Olivares et al., 1994). We however further show that in contrast to epitopes 554–625 which are affected by calcium only minimally, the epitopes
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Introduction The hypoglossal nucleus is the nucleus of the
2022-04-08

Introduction The hypoglossal nucleus is the nucleus of the twelfth cranial nerve and is located on both sides of the mid line in the dorsal medulla oblongata and is situated between the proximal end of the medullary central canal and the beginning of the fourth ventricle (Tomasch and Etemadi, 1962)
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br Regulation of Glu transporters The pivotal role of Glu
2022-04-08

Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino 73122 calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcription
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Fig demonstrates placental amino acid transporter
2022-04-08

Fig. 7 demonstrates placental amino Phusion high-fidelity DNA polymerase mg transporter protein concentrations. While no change in the placental SNAT2 is effected in response to a high-fat diet in wt, a trend toward a reduction was seen in glut3 mice in response to a high-fat vs. chow diet (Fig. 7A
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In the GLUT family glucose transporter GLUT
2022-04-08

In the GLUT family, glucose transporter 1(GLUT1) is primarily responsible for basal glucose uptake and maintenance of glucose basal metabolism in cells (Olson and Pessin, 1996). High GLUT1 expression occurred in various types of human cancers, like brain tumor, lung cancer and esophageal cancer (Nis
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The plasma levels of glucose and amino acids
2022-04-08

The plasma levels of glucose and amino acids at day likely represent the function in utero since the blood was collected within 2h after birth. To elucidate the roles of intestinal transporters as determinants of plasma levels of glucose and amino acids, we analyzed the correlation between the expre
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br Introduction Maintaining blood glucose within an
2022-04-08

Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The fmoc-osu synthesis is especially dependent on an adequate, continuous supply of circulating gluc
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br GR Is a Transcriptional Activator
2022-04-08

GR Is a Transcriptional Activator How GR activates some genes while repressing others remains unsettled after decades of study. While significant controversy exists regarding GR-mediated repression, a consensus model for transcriptional activation has emerged: GR activates transcription through s
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Similarly Somavarapu and Kepp constructed a
2022-04-07

Similarly, Somavarapu and Kepp [29] constructed a PS1 homology model using 4HYG as a template, plus modeling the TM6-TM7 intracellular segment (amino acids 273 to 374). In this study, the authors considered for the first time the mature and immature (not autoproteolyzed) forms of PS1 component, sinc
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Tanshinone IIA---sulfonic sodium Although NCT undergoes comp
2022-04-07

Although NCT undergoes complex glycosylation processing for maturation through trafficking from endoplasmic reticulum to Golgi or additional compartments, the effect of NCT glycosylation on γ-secretase activity and substrate specificity is still unknown. The present study focused on glycosylation st
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A single ICV injection of GALP
2022-04-07

A single ICV injection of GALP stimulated food intake in goldfish at 1h post-administration. This result is similar to that observed in rats, where ICV injection of GALP exerted an acute orexigenic effect [14], [15], [16]. Simultaneously, our findings counter the results found in mice, where central
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